The Give a Dog a Genome project is a hugely ambitious initiative run by the Kennel Club Genetics Centre at the Animal Health Trust to create the UK’s largest canine genome bank by sequencing the entire genome of one dog from each of 77 dog breeds. It was launched early in 2016 and is co-funded by the KC Charitable Trust. You can read about it in more depth here
The IWHG has taken advantage of the KC offer to match-fund each sequence. For this project the cost of sequencing one genome was set at £2,000; the IWHG have provided £1,000 while the KC have match-funded that amount to provide the £2,000 needed to sequence one Wolfhound genome.
The Give a Dog a Genome project will sequence one Wolfhound with osteosarcoma, which the IWHG indicated was a major health issue in Irish Wolfhounds. Dr Starkey's osteosarcoma project will sequence a further four Wolfhounds with osteosarcoma and one not affected by osteosarcoma and not carrying the chromosome 11 markers identified by Dr Starkey’s team as increasing the risk of osteosarcoma development, this has been separately funded by the IWHG. (Read about the AHT osteosarcoma project here
) This will give them the entire genome sequences of six Wolfhounds to compare 'affected by osteosarcoma' to 'unaffected by osteosarcoma', compare the Wolfhound sequence to the reference Boxer sequence, and also compare the Wolfhound genome to breeds identified as being at lower than average risk of developing osteosarcoma from the GADAG project.